Bupivacaine Hydrochloride + Dextrose

Generic Details

Generic Name

Bupivacaine Hydrochloride Dextrose

Other Names

  • Bupivacaine-Dextrose Solution

Drug Class

  • Local Anesthetic

Chemical Formula

C18H28N2O.ClH.C6H12O6

Molecular Weight

406.95 g/mol

Mechanism of Action

  • Blocks voltage-gated sodium channels, inhibiting the influx of sodium ions and preventing the initiation and conduction of nerve impulses

Indications

  • Local anesthesia for surgery, postoperative pain management, nerve block

Common Dosage Forms

  • Solution for injection

Typical Dosage

  • Varies based on the procedure and patient's age/weight

Pediatric Dosage

  • Individualized based on weight and age

Geriatric Dosage

  • Lower doses may be required due to decreased metabolism

Side Effects

  • Hypotension, bradycardia, arrhythmias, dizziness, nausea, headache, injection site reactions

Contraindications

  • Hypersensitivity to amide-type anesthetics, severe hypotension, heart block, etc.

Pregnancy Category

  • C

Lactation Safety

  • Limited data available, caution advised

Drug Interactions

  • Antiarrhythmics, beta-blockers, other local anesthetics

Overdose Symptoms

  • Central nervous system and cardiovascular toxicity, seizures, respiratory depression

Antidote for Overdose

  • Intralipid emulsion therapy

Storage Conditions

  • Store at controlled room temperature between 15-30°C (59-86°F)

Pharmacokinetics

  • Absorption: Rapidly absorbed after injection
  • Distribution: Widely distributed in tissues, crosses the placenta
  • Metabolism: Metabolized in the liver
  • Excretion: Excreted mainly in the urine

Precautions

  • Monitor vital signs during administration, have resuscitation equipment available

Warnings

  • Avoid intravascular administration, accidental intrathecal injection can result in neurotoxicity

Others

  • Should be administered by healthcare professionals trained in anesthesia