Moxifloxacin Hydrochloride + Xanthan Gum
Generic Details
Generic Name
Moxifloxacin Hydrochloride Xanthan Gum
Other Names
- Moxifloxacin Xanthan Gum Blend
Drug Class
- Fluoroquinolone Antibiotic
Chemical Formula
C21H24FN3O4.HCl
Molecular Weight
437.89 g/mol
Mechanism of Action
- Inhibits bacterial DNA replication by inhibiting DNA gyrase and topoisomerase IV enzymes
Indications
- Bacterial infections of the respiratory tract, skin, and urinary tract
Common Dosage Forms
- Oral tablet
- Ophthalmic solution
Typical Dosage
- 400 mg orally once daily
- One to two drops of ophthalmic solution in the affected eye(s) every 4 hours
Pediatric Dosage
- Dosage adjustments may be required
Geriatric Dosage
- Dosage adjustments may be required
Side Effects
- Nausea
- Diarrhea
- Headache
- Dizziness
- Tendon rupture
- QT prolongation
Contraindications
- Hypersensitivity to fluoroquinolones
- Tendon disorders
Pregnancy Category
- C - Risk cannot be ruled out
Lactation Safety
- L3 - Moderately safe
Drug Interactions
- Warfarin
- Probenecid
- Corticosteroids
Overdose Symptoms
- Tremors
- Seizures
- Confusion
Antidote for Overdose
- No specific antidote, manage symptoms
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Distributed widely in tissues
- Metabolism: Metabolized in the liver
- Excretion: Primarily excreted in the urine
Precautions
- Avoid in patients with a history of tendon disorders
- Monitor for signs of peripheral neuropathy
Warnings
- May increase the risk of tendinitis and tendon rupture
Others
- Administer with caution in elderly patients due to an increased risk of QT prolongation