Hydroxypropyl Methylcellulose

Generic Details

Generic Name

Hydroxypropyl-methylcellulose

Other Names

  • HPMC
  • Hypromellose

Drug Class

  • Ophthalmic lubricant
  • Viscosupplement

Chemical Formula

C56H108O30

Molecular Weight

1287.5 g/mol

Mechanism of Action

  • Forms a lubricating layer on the ocular surface
  • Viscosupplement for joint lubrication

Indications

  • Dry eyes
  • Ophthalmic irritation
  • Articular lubrication in osteoarthritis

Common Dosage Forms

  • Eye drops
  • Eye ointment
  • Intra-articular injection

Typical Dosage

  • 1-2 drops in the affected eye every 4 hours
  • Articular injection as per physician recommendation

Pediatric Dosage

  • Consult pediatrician for appropriate dosage

Geriatric Dosage

  • Dose adjustment may be needed, consult healthcare provider

Side Effects

  • Temporary blurred vision
  • Mild eye irritation
  • Rarely allergic reactions

Contraindications

  • Hypersensitivity to hydroxypropyl-methylcellulose

Pregnancy Category

  • Category C - Consult healthcare provider before use

Lactation Safety

  • Safety not established - Consult healthcare provider before use

Drug Interactions

  • No significant drug interactions reported

Overdose Symptoms

  • Excessive eye irritation
  • Vision disturbances

Antidote for Overdose

  • Rinse eyes thoroughly with water
  • Consult healthcare provider

Storage Conditions

  • Store at room temperature away from direct sunlight and moisture

Pharmacokinetics

  • Absorption: Minimal systemic absorption after ophthalmic use
  • Distribution: Limited distribution in the body
  • Metabolism: Not metabolized significantly
  • Excretion: Excreted unchanged primarily via urine

Precautions

  • Avoid contaminating the dropper tip
  • Do not use if solution changes color or becomes cloudy

Warnings

  • Discontinue use if irritation persists or worsens
  • Consult doctor if using for more than 1 week continuously

Others

  • Do not use the product if the seal is broken or tampered