Hypromellose

Generic Details

Generic Name

Hypromellose

Other Names

  • Hydroxypropyl Methylcellulose
  • HPMC

Drug Class

  • Viscosity enhancing agent
  • Ophthalmic lubricant

Chemical Formula

C56H108O30

Molecular Weight

1282.49 g/mol

Mechanism of Action

  • Hypromellose acts as a lubricant and improves viscosity in the eye, providing relief from dryness or irritation.

Indications

  • Dry eyes
  • Eye irritation
  • Contact lens discomfort

Common Dosage Forms

  • Eye drops
  • Eye ointment
  • Oral tablets

Typical Dosage

  • 1 to 2 drops in the affected eye(s) as needed

Pediatric Dosage

  • Consult a pediatrician for appropriate dosage

Geriatric Dosage

  • No specific dosage adjustment necessary

Side Effects

  • Blurred vision
  • Eye irritation
  • Stinging or burning sensation in the eye

Contraindications

  • Hypersensitivity to hypromellose or any component of the formulation

Pregnancy Category

  • Category C - Animal reproduction studies have shown an adverse effect on the fetus

Lactation Safety

  • It is not known whether hypromellose is excreted in human milk

Drug Interactions

  • No known significant drug interactions

Overdose Symptoms

  • Excessive eye irritation
  • Vision changes

Antidote for Overdose

  • Rinse eyes thoroughly with water and seek medical attention

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Limited systemic absorption after ocular administration
  • Distribution: Not well characterized
  • Metabolism: Not metabolized
  • Excretion: Mainly eliminated unchanged in the feces

Precautions

  • Avoid contact with other ophthalmic solutions within 5 minutes
  • Do not touch the dropper tip to prevent contamination

Warnings

  • Discontinue use if irritation persists or worsens
  • Consult a doctor before using in case of eye pain or persistent redness

Others

  • Always check the expiration date before use