Ibandronic Acid + Coral Calcium + Vitamin D3

Generic Details

Generic Name

Ibandronic Acid Coral Calcium Vitamin D3

Other Names

  • ibandronate calcium coral calcium cholecalciferol
  • ibandronate coral calcium vitamin D3

Drug Class

  • Bisphosphonate

Chemical Formula

C34H62CaN2O8

Molecular Weight

710.24 g/mol

Mechanism of Action

  • Ibandronic acid inhibits osteoclast activity and prevents bone resorption.

Indications

  • Osteoporosis
  • Bone loss
  • Vitamin D3 deficiency

Common Dosage Forms

  • Tablet
  • Oral Solution

Typical Dosage

  • 150 mg ibandronate once monthly
  • 500 mg coral calcium daily
  • 1000 IU vitamin D3 daily

Pediatric Dosage

  • Not established

Geriatric Dosage

  • Dosage adjustment may be required based on renal function

Side Effects

  • Nausea
  • Abdominal pain
  • Heartburn
  • Muscle pain
  • Headache

Contraindications

  • Hypocalcemia
  • Inability to stand or sit upright for at least 60 minutes

Pregnancy Category

  • Category C - Risk cannot be ruled out

Lactation Safety

  • Not recommended; excretion in breast milk unknown

Drug Interactions

  • Antacids
  • NSAIDs
  • Certain antibiotics

Overdose Symptoms

  • Hypocalcemia
  • Hypophosphatemia
  • Hypomagnesemia

Antidote for Overdose

  • Symptomatic and supportive treatment; consider calcium, magnesium, and phosphate replacement

Storage Conditions

  • Store at controlled room temperature (20-25°C)

Pharmacokinetics

  • Absorption: Ibandronate: <1% absorbed in the gastrointestinal tract
  • Distribution: Extensively bound to bone
  • Metabolism: Not metabolized
  • Excretion: Primarily via urine

Precautions

  • Renal impairment
  • Hypocalcemia risk
  • Esophageal abnormalities

Warnings

  • Risk of esophageal adverse reactions
  • Atypical femur fractures
  • Osteonecrosis of the jaw

Others

  • Consider calcium and vitamin D supplementation