Prucalopride Succinate

Generic Details

Generic Name

Prucalopride Succinate

Other Names

  • Prucalopride

Drug Class

  • Gastrointestinal Motility Stimulant

Chemical Formula

C18H26ClN3O3.C4H6O4

Molecular Weight

463.93 g/mol

Mechanism of Action

  • Selective serotonin type 4 (5-HT4) receptor agonist

Indications

  • Chronic idiopathic constipation

Common Dosage Forms

  • Tablet

Typical Dosage

  • 2 mg once daily

Pediatric Dosage

  • Not established

Geriatric Dosage

  • No dosage adjustment necessary

Side Effects

  • Headache
  • Nausea
  • Diarrhea
  • Abdominal pain
  • Flatulence

Contraindications

  • Hypersensitivity to prucalopride
  • Intestinal perforation or obstruction
  • Severe inflammatory conditions of the gastrointestinal tract

Pregnancy Category

  • Category C - Animal studies show adverse effects, but potential benefits may warrant its use in pregnant women despite risks.

Lactation Safety

  • Not recommended. Limited data available.

Drug Interactions

  • Avoid concomitant use with strong CYP3A4 inhibitors

Overdose Symptoms

  • Symptomatic treatment advised

Antidote for Overdose

  • No specific antidote known

Storage Conditions

  • Store at room temperature away from moisture and heat.

Pharmacokinetics

  • Absorption: Rapidly absorbed
  • Distribution: Volume of distribution is approximately 90 L
  • Metabolism: Hepatic
  • Excretion: Primarily in feces (60-70%)

Precautions

  • Monitor for signs of intestinal perforation or obstruction
  • Caution in patients with hepatic impairment

Warnings

  • May cause severe diarrhea; discontinue if severe symptoms occur

Others

  • Prucalopride is not recommended for use in patients under 18 years of age.