Albendazole
Generic Details
Generic Name
Albendazole
Other Names
- Albenza
- Zentel
Drug Class
- Anthelmintic
Chemical Formula
C12H15N3O2S
Molecular Weight
265.33 g/mol
Mechanism of Action
- Inhibits microtubule formation in parasites, leading to their immobilization and death
Indications
- Treatment of parasitic worm infections such as neurocysticercosis, hydatid disease, and intestinal infections caused by roundworms, hookworms, and pinworms
Common Dosage Forms
- Tablet
- Suspension
Typical Dosage
- 400 mg as a single dose for certain parasitic infections, or as prescribed by a healthcare provider
Pediatric Dosage
- Dosing based on weight and specific indications; consult a pediatric healthcare provider
Geriatric Dosage
- Adjust dosage based on renal function
Side Effects
- Nausea
- Vomiting
- Headache
- Dizziness
- Abdominal pain
- Elevated liver enzymes
Contraindications
- Hypersensitivity to albendazole or its components
Pregnancy Category
- C - Use with caution
Lactation Safety
- Limited data available; use with caution
Drug Interactions
- Cimetidine
- Dexamethasone
- Praziquantel
Overdose Symptoms
- Liver toxicity
- Bone marrow suppression
Antidote for Overdose
- No specific antidote; symptomatic and supportive treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract
- Distribution: Widely distributed in body tissues
- Metabolism: Metabolized in the liver to its active form
- Excretion: Excreted in the urine
Precautions
- Monitor liver function tests during therapy
- Avoid pregnancy during treatment and for 1 month after therapy
Warnings
- Risk of liver toxicity; assess liver function prior to initiation and during therapy