Estriol (Vaginal)
Generic Details
Generic Name
Estriol-Vaginal
Other Names
- Estriol Cream
Drug Class
- Estrogen
Chemical Formula
C18H24O3
Molecular Weight
288.38 g/mol
Mechanism of Action
- Estriol binds to estrogen receptors and exerts estrogenic effects.
Indications
- Treatment of vaginal dryness, irritation, and itching due to menopause
Common Dosage Forms
- Vaginal cream
- Vaginal suppositories
Typical Dosage
- Initially, apply 0.5-2 g of cream intravaginally daily for 2-4 weeks, then reduce to 1-3 times per week as maintenance
Pediatric Dosage
- Not established
Geriatric Dosage
- Use with caution, dose adjustment may be required in elderly patients
Side Effects
- Local irritation
- Itching
- Burning sensation
- Discharge
- Rarely systemic effects if used at high doses
Contraindications
- Pregnancy
- Breastfeeding
- Undiagnosed vaginal bleeding
- Known or suspected estrogen-dependent malignant tumors
Pregnancy Category
- Not recommended for use during pregnancy
Lactation Safety
- Not recommended for use during breastfeeding
Drug Interactions
- May interact with certain anticoagulants and liver enzyme inducers. Consult healthcare provider before use
Overdose Symptoms
- Excessive vaginal bleeding
- Nausea
- Vomiting
- Breast tenderness
Antidote for Overdose
- No specific antidote, symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed through vaginal mucosa
- Distribution: Distributed to target tissues in the pelvis
- Metabolism: Metabolized in the liver
- Excretion: Primarily excreted in urine
Precautions
- Regular gynecological examinations recommended during long-term use
- Discontinue use if any sudden, unexplained vaginal bleeding occurs
Warnings
- Increased risk of endometrial hyperplasia in women with intact uterus when used without progestogen
Others
- Estriol is a weaker estrogen compared to estradiol and estrone, which may result in fewer side effects.