Betamethasone Valerate

Generic Details

Generic Name

Betamethasone Valerate

Other Names

  • Betamethasone-17-valerate

Drug Class

  • Corticosteroid

Chemical Formula

C27H37FO6

Molecular Weight

476.59 g/mol

Mechanism of Action

  • Betamethasone Valerate binds to specific cytoplasmic receptors to induce anti-inflammatory effects, immunosuppression, and vasoconstriction.

Indications

  • Eczema
  • Psoriasis
  • Dermatitis
  • Allergic reactions
  • Skin irritations

Common Dosage Forms

  • Topical cream
  • Ointment
  • Lotion

Typical Dosage

  • Apply a thin film to the affected skin areas 1-2 times daily

Pediatric Dosage

  • Use with caution under pediatrician's supervision

Geriatric Dosage

  • Dosage adjustments may be needed in elderly patients

Side Effects

  • Skin irritation
  • Burning sensation
  • Redness
  • Dryness
  • Thinning of skin with prolonged use

Contraindications

  • Hypersensitivity to corticosteroids
  • Skin infections

Pregnancy Category

  • Category C - Consult healthcare provider before use

Lactation Safety

  • Consider benefits versus risks before use during lactation

Drug Interactions

  • No significant drug-drug interactions reported

Overdose Symptoms

  • Excessive skin redness
  • Swelling
  • Blistering

Antidote for Overdose

  • No specific antidote, symptomatic treatment recommended

Storage Conditions

  • Store at controlled room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Well absorbed through the skin
  • Distribution: Not well defined
  • Metabolism: Hepatic metabolism
  • Excretion: Primarily renal

Precautions

  • Avoid prolonged use on the face or near eyes
  • Do not cover the treated area with airtight dressings unless directed by a healthcare provider

Warnings

  • Discontinue if irritation or sensitization occurs
  • Use with caution in patients with hepatic impairment

Others

  • Avoid sudden discontinuation after prolonged use, taper off dosage gradually