Betamethasone Sodium Phosphate
Generic Details
Generic Name
Betamethasone Sodium Phosphate
Other Names
- Betamethasone Phosphate
- Betamethasone Sodium
Drug Class
- Corticosteroid
Chemical Formula
C22H29FO8P
Molecular Weight
466.43 g/mol
Mechanism of Action
- Anti-inflammatory
- Immunosuppressant
Indications
- Inflammatory skin conditions
- Allergic reactions
- Rheumatic disorders
- Asthma exacerbations
Common Dosage Forms
- Cream
- Ointment
- Lotion
- Gel
Typical Dosage
- Apply a thin layer to affected area once or twice daily
Pediatric Dosage
- Dosage based on weight and condition severity, consult pediatrician
Geriatric Dosage
- Lower initial doses may be required due to decreased liver function
Side Effects
- Skin thinning
- Skin discoloration
- Topical steroid withdrawal syndrome
- Increased risk of infections
Contraindications
- Hypersensitivity to corticosteroids
- Untreated fungal, bacterial, or viral infections
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Minimal risk, consider alternative medications
Drug Interactions
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Insulin
- Rifampin
Overdose Symptoms
- Severe skin reactions
- Fluid retention
- Elevated blood pressure
Antidote for Overdose
- No specific antidote, supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well-absorbed topically
- Distribution: Distributed widely in the body
- Metabolism: Metabolized in the liver
- Excretion: Excreted in urine
Precautions
- Use caution on broken or infected skin
- Avoid excessive use or prolonged treatment duration
Warnings
- May cause adrenal suppression if used for long periods
- Discontinue gradually to avoid rebound effects