Moxifloxacin Hydrochloride (Injection)

Generic Details

Generic Name

Moxifloxacin Hydrochloride Injection

Other Names

  • Moxifloxacin HCl Injection
  • Moxifloxacin IV

Drug Class

  • Fluoroquinolone Antibiotic

Chemical Formula

C21H24FN3O4 · HCl

Molecular Weight

437.90 g/mol

Mechanism of Action

  • Inhibits DNA gyrase and topoisomerase IV enzymes in bacteria

Indications

  • Treatment of bacterial infections such as respiratory infections, skin infections, intra-abdominal infections, and urinary tract infections

Common Dosage Forms

  • Solution for Injection

Typical Dosage

  • 400 mg once daily administered by intravenous infusion over 60 minutes

Pediatric Dosage

  • Dosage adjustment based on weight and severity of infection

Geriatric Dosage

  • No adjustment necessary in the absence of renal impairment

Side Effects

  • Nausea
  • Diarrhea
  • Headache
  • Dizziness
  • Insomnia
  • Rash

Contraindications

  • Hypersensitivity to moxifloxacin or other fluoroquinolones
  • Tendon inflammation or rupture history

Pregnancy Category

  • C - Use with caution if benefits outweigh risks

Lactation Safety

  • Compatible with breastfeeding, monitor for diarrhea or rash in the infant

Drug Interactions

  • Avoid concomitant use with other QT-prolonging drugs
  • Antacids and multivitamins may reduce absorption

Overdose Symptoms

  • Acute renal failure
  • Liver damage
  • Central nervous system effects

Antidote for Overdose

  • No specific antidote, provide supportive care

Storage Conditions

  • Store at controlled room temperature (20-25°C)
  • Protect from light and freezing

Pharmacokinetics

  • Absorption: Well-absorbed after intravenous administration
  • Distribution: Penetrates well into tissues and body fluids
  • Metabolism: Metabolized in the liver to inactive metabolites
  • Excretion: Excreted mainly via the urine and feces

Precautions

  • Monitor for signs of hypersensitivity reactions
  • Caution in patients with CNS disorders or myasthenia gravis

Warnings

  • May cause serious adverse effects including tendon inflammation and peripheral neuropathy

Others

  • Complete the full course of treatment even if feeling better to prevent resistance