Elagolix Sodium

Generic Details

Generic Name

Elagolix-sodium

Other Names

  • Elagolix Na

Drug Class

  • Gonadotropin-releasing hormone (GnRH) antagonist

Chemical Formula

C32H29F5N3NaO5

Molecular Weight

669.57 g/mol

Mechanism of Action

  • Elagolix-sodium inhibits gonadotropin secretion, thereby reducing estrogen levels.

Indications

  • Treatment of endometriosis
  • Management of heavy menstrual bleeding associated with uterine fibroids

Common Dosage Forms

  • Oral tablet

Typical Dosage

  • 150 mg once daily for endometriosis
  • 300 mg once daily for uterine fibroids

Pediatric Dosage

  • Safety and efficacy not established in pediatric patients

Geriatric Dosage

  • Dose adjustment may be necessary based on renal function in elderly patients

Side Effects

  • Hot flashes
  • Headache
  • Nausea
  • Diarrhea
  • Insomnia

Contraindications

  • Pregnancy
  • Severe hepatic impairment

Pregnancy Category

  • X - Contraindicated in pregnancy

Lactation Safety

  • Not recommended during breastfeeding

Drug Interactions

  • Strong CYP3A4 inhibitors may increase elagolix levels
  • Strong CYP3A4 inducers may decrease elagolix levels

Overdose Symptoms

  • Potential for QT prolongation, dizziness, and headache

Antidote for Overdose

  • No specific antidote, symptomatic and supportive treatment

Storage Conditions

  • Store at room temperature (20-25°C)
  • Protect from light and moisture

Pharmacokinetics

  • Absorption: Rapidly absorbed
  • Distribution: High volume of distribution
  • Metabolism: Metabolized by CYP3A4 enzymes
  • Excretion: Mainly excreted in feces

Precautions

  • Use with caution in patients with hepatic impairment
  • Monitor bone mineral density in long-term use

Warnings

  • May cause bone loss with prolonged use
  • May decrease bone mineral density