Drospirenone

Generic Details

Generic Name

Drospirenone

Other Names

  • DRSP

Drug Class

  • Progestin

Chemical Formula

C24H30O3

Molecular Weight

366.49 g/mol

Mechanism of Action

  • Antiandrogenic and antimineralocorticoid properties
  • Progestogenic activity

Indications

  • Oral contraceptive
  • Treatment of premenstrual dysphoric disorder (PMDD)
  • Treatment of moderate acne in women seeking contraception

Common Dosage Forms

  • Oral tablets

Typical Dosage

  • 3 mg once daily for 21 days, followed by 7 days without drug

Pediatric Dosage

    Geriatric Dosage

      Side Effects

      • Nausea
      • Headache
      • Breast pain
      • Irregular vaginal bleeding
      • Mood changes

      Contraindications

      • Hypersensitivity to drospirenone or any component of the formulation
      • Thromboembolic disorders
      • Liver disease

      Pregnancy Category

      • X - Contraindicated

      Lactation Safety

      • Limited data available, caution advised

      Drug Interactions

      • Potentially increases potassium levels; avoid concomitant use with potassium-sparing diuretics, ACE inhibitors, angiotensin receptor blockers, NSAIDs

      Overdose Symptoms

      • Nausea
      • Vomiting
      • Bleeding

      Antidote for Overdose

      • No specific antidote, manage symptoms and provide supportive care

      Storage Conditions

      • Store at room temperature away from moisture and heat

      Pharmacokinetics

      • Absorption: Well absorbed from the gastrointestinal tract
      • Distribution: High plasma protein binding
      • Metabolism: Extensive hepatic metabolism
      • Excretion: Mainly renal excretion

      Precautions

      • Monitor potassium levels periodically especially in patients at risk for hyperkalemia

      Warnings

      • Increased risk of venous thromboembolism
      • Increased risk of hyperkalemia, particularly in patients with renal insufficiency or on concomitant medications that increase potassium levels

      Others

      • Drospirenone is a synthetic progestin with spironolactone-like properties.