Dequalinium Chloride

Generic Details

Generic Name

Dequalinium-Chloride

Other Names

  • Diquasol
  • Fluomizol

Drug Class

  • Antiseptic
  • Antifungal

Chemical Formula

C30H40Cl2N2

Molecular Weight

509.56 g/mol

Mechanism of Action

  • Disruption of microbial cell membranes

Indications

  • Topical treatment of bacterial and fungal infections in the mouth and throat
  • Vaginal infections

Common Dosage Forms

  • Mouthwash
  • Vaginal cream

Typical Dosage

  • For mouthwash: 10-20 mg/mL solution, used for gargling several times a day
  • For vaginal cream: Apply a pea-sized amount intravaginally once or twice daily

Pediatric Dosage

  • Dosage adjustment may be needed based on age and weight

Geriatric Dosage

  • Use with caution and may require dosage adjustment based on renal function

Side Effects

  • Local irritation or burning sensation at the application site
  • Allergic reactions such as rashes or itching

Contraindications

  • Hypersensitivity to dequalinium-chloride or any component of the formulation

Pregnancy Category

  • Category B - Animal reproduction studies have failed to demonstrate a risk to the fetus

Lactation Safety

  • May be used cautiously during breastfeeding

Drug Interactions

  • No significant drug interactions reported

Overdose Symptoms

  • Unlikely due to topical application, but excessive oral ingestion may cause gastrointestinal irritation

Antidote for Overdose

  • Symptomatic treatment

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Limited systemic absorption
  • Distribution: Primarily localized to the site of application
  • Metabolism: Minimal metabolism
  • Excretion: Mainly excreted unchanged in urine

Precautions

  • Avoid contact with eyes
  • Do not swallow oral formulations

Warnings

  • Not for systemic use or internal ingestion
  • Discontinue use if irritation persists

Others

  • May cause temporary discoloration of the tongue with oral use