Esomeprazole (MUPS preparation)

Generic Details

Generic Name

Esomeprazole-MUPS-Preparation

Other Names

  • Esomeprazole

Drug Class

  • Proton Pump Inhibitor

Chemical Formula

C17H19N3O3S

Molecular Weight

345.42 g/mol

Mechanism of Action

  • Inhibits gastric acid secretion by irreversibly blocking the proton pump in parietal cells of the stomach.

Indications

  • Gastroesophageal reflux disease (GERD)
  • Peptic ulcer disease
  • Zollinger-Ellison syndrome
  • Helicobacter Pylori eradication in combination therapy
  • Prevention of NSAID-induced ulcers

Common Dosage Forms

  • Delayed-release capsules
  • Oral suspension

Typical Dosage

  • 20-40 mg once daily

Pediatric Dosage

  • Dosage based on weight and severity of condition

Geriatric Dosage

  • Adjust dosage based on renal function

Side Effects

  • Headache
  • Nausea
  • Diarrhea
  • Abdominal pain
  • Vitamin B12 deficiency with long-term use

Contraindications

  • Hypersensitivity to esomeprazole or other proton pump inhibitors
  • Co-administration with rilpivirine-containing products

Pregnancy Category

  • Category B

Lactation Safety

  • Limited data available, cautious use recommended

Drug Interactions

  • Warfarin
  • Clopidogrel
  • Digoxin
  • Antiretroviral drugs

Overdose Symptoms

  • Confusion
  • Drowsiness
  • Blurred vision
  • Dry mouth

Antidote for Overdose

  • No specific antidote, symptomatic treatment recommended

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Rapidly absorbed from the gastrointestinal tract
  • Distribution: Highly protein-bound
  • Metabolism: Primarily hepatic through CYP2C19 and CYP3A4
  • Excretion: Mainly excreted in urine

Precautions

  • Monitor magnesium levels during long-term use
  • Consider dose adjustment in liver impairment

Warnings

  • Increased risk of Clostridium difficile-associated diarrhea
  • Potential for stomach cancer with long-term use

Others

  • May be administered with or without food