Indacaterol + Glycopyrronium
Generic Details
Generic Name
Indacaterol-glycopyrronium
Other Names
- Ultibro Breezhaler
- Xoterna Breezhaler
Drug Class
- Long-acting beta-agonist (LABA)
- Long-acting muscarinic antagonist (LAMA)
Chemical Formula
C24H28N2O8(C19H28BrNO3)
Molecular Weight
614.49 g/mol
Mechanism of Action
- Indacaterol: Selective beta2-adrenergic receptor agonist
- Glycopyrronium: Muscarinic receptor antagonist
Indications
- Chronic obstructive pulmonary disease (COPD)
Common Dosage Forms
- Inhalation powder
- Inhalation solution
Typical Dosage
- One inhalation once daily
Pediatric Dosage
- Safety and efficacy not established in children
Geriatric Dosage
- No dose adjustment necessary
Side Effects
- Headache
- Nasopharyngitis
- Cough
- Oral candidiasis
- Bronchitis
Contraindications
- Hypersensitivity to indacaterol or glycopyrronium
- Severe hypersensitivity to milk proteins
Pregnancy Category
- Category C
Lactation Safety
- Caution advised
Drug Interactions
- Avoid concomitant use with other long-acting beta-agonists or anticholinergics
Overdose Symptoms
- Tachycardia
- Tremor
- Hypokalemia
Antidote for Overdose
- Symptomatic and supportive treatment
Storage Conditions
- Store in a dry place at room temperature
Pharmacokinetics
- Absorption: Rapidly absorbed following inhalation
- Distribution: Highly bound to plasma proteins
- Metabolism: Primarily hepatic
- Excretion: Mainly through feces
Precautions
- Patients with cardiovascular disorders
- Patients with known hypersensitivity reactions
Warnings
- Not indicated for the treatment of asthma
- Titrate with caution in patients with narrow-angle glaucoma