Ethinyl Estradiol + Lynestrenol (0.05 mg)
Generic Details
Generic Name
Ethinyl Estradiol and Lynestrenol 0.05 mg
Other Names
- Ethinylestradiol and Lynestrenol 0.05 mg
- Combined Oral Contraceptive Pill - 0.05 mg
Drug Class
- Combination Oral Contraceptive
Chemical Formula
C22H28O2
Molecular Weight
324.46 g/mol
Mechanism of Action
- Inhibition of ovulation
- Thickening of cervical mucus
- Changing the endometrial lining
Indications
- Prevention of pregnancy
- Regulation of menstrual cycle
- Treatment of acne in females
- Treatment of hirsutism
Common Dosage Forms
- Oral tablet
Typical Dosage
- 1 tablet daily for 21 days, then 7 days off
Pediatric Dosage
- Not recommended in young girls before menarche
Geriatric Dosage
- No specific dosage adjustments needed in the elderly
Side Effects
- Nausea
- Headache
- Breast tenderness
- Breakthrough bleeding
- Weight changes
- Mood changes
Contraindications
- Pregnancy
- History of blood clots
- Liver disease
- Breast cancer
Pregnancy Category
- Category X - Contraindicated in pregnancy
Lactation Safety
- Small amounts of hormonal components may be excreted in breast milk
Drug Interactions
- Antibiotics (e.g., rifampicin) may decrease efficacy
- Antiepileptics (e.g., carbamazepine) may decrease efficacy
Overdose Symptoms
- Nausea
- Vomiting
- Vaginal bleeding
Antidote for Overdose
- No specific antidote, symptomatic treatment
Storage Conditions
- Store at room temperature (20-25°C)
- Protect from light and moisture
Pharmacokinetics
- Absorption: Well-absorbed from the gastrointestinal tract
- Distribution: Binds to serum albumin and sex hormone-binding globulin
- Metabolism: Metabolized in the liver
- Excretion: Excreted mainly in urine and feces
Precautions
- Regular monitoring for side effects
- Smoking increases the risk of cardiovascular side effects
Warnings
- Increased risk of blood clots especially in smokers over 35 years old
- Increased risk of cardiovascular events
Others
- Patients should be educated on proper use and missed pill instructions