Acidic component [HCO3 Hemodialysis Solution]

Generic Details

Generic Name

Acidic Component HCO3 Hemodialysis Solution

Other Names

  • Bicarbonate Hemodialysis Solution

Drug Class

  • Dialysis Solution

Chemical Formula

HCO3-

Molecular Weight

61.0168 g/mol

Mechanism of Action

  • Corrects metabolic acidosis during hemodialysis by buffering excess hydrogen ions.

Indications

  • Treatment of metabolic acidosis during hemodialysis.

Common Dosage Forms

  • Solution for intravenous infusion

Typical Dosage

  • Individualized based on patient's condition and acid-base status

Pediatric Dosage

  • Dosage adjustments may be needed based on weight and age

Geriatric Dosage

  • May require lower doses or longer intervals between doses in elderly patients

Side Effects

  • Hypokalemia
  • Hypoventilation
  • Metabolic alkalosis

Contraindications

  • Hypokalemia
  • Alkalosis
  • Hypocalcemia
  • Fluid overload

Pregnancy Category

  • C - Safety in pregnancy has not been established

Lactation Safety

  • Not recommended for use in breastfeeding mothers

Drug Interactions

  • Potassium-sparing diuretics may increase the risk of hyperkalemia

Overdose Symptoms

  • Severe metabolic alkalosis
  • Hypokalemia

Antidote for Overdose

  • Administer potassium supplementation cautiously under medical supervision

Storage Conditions

  • Store at controlled room temperature (20-25°C)

Pharmacokinetics

  • Absorption: Administered intravenously and rapidly equilibrates in the extracellular fluid compartment.
  • Distribution: Distribution volume depends on patient's fluid status.
  • Metabolism: Bicarbonate is metabolized in the liver.
  • Excretion: Excreted in the urine.

Precautions

  • Monitor electrolyte levels regularly during therapy.

Warnings

  • Not for direct intravenous injection without appropriate dilution.

Others

  • Close monitoring of acid-base status is essential during hemodialysis.