Terlipressin Acetate

Generic Details

Generic Name

Terlipressin Acetate

Other Names

    Drug Class

    • Vasopressin Analog

    Chemical Formula

    C52H74N16O15S2

    Molecular Weight

    1227.38 g/mol

    Mechanism of Action

    • Vasoconstrictor
    • Vasopressin Receptor Agonist

    Indications

    • Hepatorenal Syndrome
    • Esophageal Variceal Bleeding

    Common Dosage Forms

    • Injection

    Typical Dosage

    • 1-2 mg every 4-6 hours

    Pediatric Dosage

    • Safety and efficacy not established in children

    Geriatric Dosage

    • Dose adjustment may be required

    Side Effects

    • Hypertension
    • Fluid retention
    • Headache
    • Nausea
    • Diarrhea

    Contraindications

    • Hypersensitivity to terlipressin
    • Coronary artery disease
    • Severe hypertension

    Pregnancy Category

    • Category C - Risk cannot be ruled out

    Lactation Safety

    • Use with caution, excretion in breast milk unknown

    Drug Interactions

    • Beta-blockers
    • Vasodilators
    • Diuretics

    Overdose Symptoms

    • Severe hypertension
    • Bradycardia
    • Water retention

    Antidote for Overdose

    • Supportive care and symptom management

    Storage Conditions

    • Store at room temperature (20-25°C)

    Pharmacokinetics

    • Absorption: Rapidly absorbed after parenteral administration
    • Distribution: Vd: 4-5 L/kg
    • Metabolism: Metabolized in the liver
    • Excretion: Primarily excreted in urine

    Precautions

    • Monitor blood pressure regularly
    • Use with caution in patients with renal impairment

    Warnings

    • Risk of myocardial ischemia and infarction
    • May worsen peripheral or visceral ischemia

    Others

    • Terlipressin acetate is a synthetic analog of vasopressin with longer half-life and increased selective action on V1 receptors.