Anidulafungin

Generic Details

Generic Name

Anidulafungin

Other Names

  • Eraxis

Drug Class

  • Antifungal

Chemical Formula

C58H73N7O17

Molecular Weight

1140.26 g/mol

Mechanism of Action

  • Inhibits the synthesis of β(1,3)-D-glucan, an essential component of the fungal cell wall.

Indications

  • Treatment of candidemia, esophageal candidiasis, and invasive candidiasis.

Common Dosage Forms

  • Powder for injection

Typical Dosage

  • 100 mg once daily

Pediatric Dosage

  • Safety and efficacy not established in pediatric patients

Geriatric Dosage

  • Adjust dosage based on renal function

Side Effects

  • Hepatotoxicity
  • Infusion-related reactions
  • Headache
  • Nausea
  • Hypokalemia

Contraindications

  • Hypersensitivity to anidulafungin or other echinocandins

Pregnancy Category

  • C - Use with caution if benefits outweigh risks

Lactation Safety

  • Limited data available, consult healthcare provider

Drug Interactions

  • May increase levels of sirolimus and digoxin

Overdose Symptoms

  • Potential for liver function test abnormalities

Antidote for Overdose

  • No specific antidote, manage symptoms and provide supportive care

Storage Conditions

  • Store powder for injection at controlled room temperature (20-25°C)

Pharmacokinetics

  • Absorption: Not applicable - administered intravenously
  • Distribution: Highly protein-bound
  • Metabolism: Metabolized in the liver
  • Excretion: Mainly excreted in feces

Precautions

  • Monitor liver function tests during therapy
  • Use with caution in patients with hepatic impairment

Warnings

  • Risk of liver injury
  • Hypersensitivity reactions may occur

Others

  • Ensure compatibility with intravenous equipment before administration.