Hartmann's Solution
Generic Details
Generic Name
Hartmann's Solution
Other Names
- Ringer's lactate
- Ringer-lactate solution
Drug Class
- Electrolyte solution
- Crystalloid solution
Chemical Formula
Not applicable (mixture)
Molecular Weight
Not applicable
Mechanism of Action
- Provides electrolytes and fluids for intravenous administration to restore electrolyte balance
Indications
- Dehydration
- Electrolyte imbalance
- Volume replacement therapy
Common Dosage Forms
- Injection for intravenous use
Typical Dosage
- Adults: 500-3000 ml/day depending on the condition
- Pediatrics: dosage based on weight and condition
Pediatric Dosage
- Based on weight and clinical condition of the child
Geriatric Dosage
- Adjusted based on renal function and comorbidities in the elderly
Side Effects
- Fluid overload
- Hypernatremia
- Hyperkalemia
- Metabolic alkalosis
Contraindications
- Hypersensitivity to components
- Severe hyperkalemia or hyponatremia
- Severe renal impairment
Pregnancy Category
- Category C - Caution advised, benefit should outweigh risks
Lactation Safety
- Considered safe for use during breastfeeding
Drug Interactions
- No significant drug interactions reported
Overdose Symptoms
- Fluid overload symptoms such as edema, shortness of breath
Antidote for Overdose
- Discontinue infusion and manage symptoms of fluid overload
Storage Conditions
- Store at room temperature away from light and moisture
Pharmacokinetics
- Absorption: Rapidly absorbed into circulation post intravenous administration
- Distribution: Distributed into extracellular fluid compartments
- Metabolism: Metabolized into various metabolic byproducts
- Excretion: Primarily eliminated through renal excretion
Precautions
- Monitor electrolyte levels during therapy
- Avoid rapid infusion in patients with cardiac or renal issues
Warnings
- Risk of fluid overload, especially in patients with cardiac or renal impairment
Others
- Hartmann's Solution is named after the British surgeon Sydney Ringer who formulated it in the 1880s.