Levodopa + Carbidopa (CR tablet)
Generic Details
Generic Name
Levodopa-Carbidopa-CR Tablet
Other Names
- Sinemet CR
- Duopa
Drug Class
- Antiparkinsonian
Chemical Formula
Molecular Weight
Mechanism of Action
- Levodopa is a dopamine precursor converted to dopamine in the brain. Carbidopa inhibits the peripheral breakdown of levodopa, increasing its availability in the brain.
Indications
- Parkinson's Disease
Common Dosage Forms
- Extended-Release Tablet
Typical Dosage
- One tablet 2-3 times daily
Pediatric Dosage
- Not established
Geriatric Dosage
- May require lower doses
Side Effects
- Nausea
- Vomiting
- Dizziness
- Dyskinesia
- Orthostatic Hypotension
Contraindications
- Narrow-angle glaucoma
- Use of nonselective monoamine oxidase inhibitors (MAOIs)
Pregnancy Category
- C - Risk cannot be ruled out
Lactation Safety
- Compatible with breastfeeding under healthcare provider supervision
Drug Interactions
- MAOIs
- Antipsychotics
- Metoclopramide
Overdose Symptoms
- Dyskinesias
- Hallucinations
- Hypotension
- Arrhythmias
Antidote for Overdose
- Symptomatic and supportive treatment
Storage Conditions
- Store in a cool, dry place away from light and moisture
Pharmacokinetics
- Absorption: Varies
- Distribution: Crosses the blood-brain barrier
- Metabolism: Levodopa - liver; Carbidopa - intestines
- Excretion: Primarily urine
Precautions
- Monitor for dyskinesias
- Avoid sudden withdrawal
- Caution in patients with history of psychosis or cardiovascular disease
Warnings
- May cause or exacerbate psychiatric symptoms
- May cause orthostatic hypotension