Medroxyprogesterone Acetate (Tablet)
Generic Details
Generic Name
Medroxyprogesterone Acetate Tablet
Other Names
- Provera
- Depo-Provera
Drug Class
- Progestin
Chemical Formula
C24H34O4
Molecular Weight
386.52 g/mol
Mechanism of Action
- Progestational and antiestrogenic effects
Indications
- Menstrual disorders
- Endometriosis
- Contraception
- Hormone replacement therapy
Common Dosage Forms
- Tablet
- Injection
Typical Dosage
- 2.5-10 mg once daily for 5-10 days
- Depo-Provera injection every 3 months
Pediatric Dosage
Geriatric Dosage
Side Effects
- Irregular vaginal bleeding
- Nausea
- Breast tenderness
- Headache
- Mood changes
Contraindications
- Known or suspected pregnancy
- Breast cancer
- Liver dysfunction
Pregnancy Category
- Category X - Contraindicated during pregnancy
Lactation Safety
- Caution advised, can be excreted in breast milk
Drug Interactions
- Barbiturates
- Rifampin
- St. John's Wort - may decrease efficacy
Overdose Symptoms
- Nausea
- Vomiting
- Fatigue
Antidote for Overdose
- No specific antidote, symptomatic treatment recommended
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract
- Distribution: Protein-bound and distributed widely in tissues
- Metabolism: Metabolized in the liver
- Excretion: Excreted in urine and feces
Precautions
- Monitor for signs of thromboembolism
- Regularly assess bone density in long-term use
Warnings
- Increased risk of cardiovascular events in postmenopausal women