Magnesium Oxide
Generic Details
Generic Name
Magnesium Oxide
Other Names
- Magnesia
Drug Class
- Mineral Supplement
Chemical Formula
MgO
Molecular Weight
40.3044 g/mol
Mechanism of Action
- Acts as an antacid and laxative by neutralizing stomach acid and increasing water in the intestines.
Indications
- Treatment of heartburn, indigestion, constipation, and symptoms of low magnesium levels.
Common Dosage Forms
- Tablet
- Capsule
- Liquid
Typical Dosage
- 400-800 mg orally once daily
Pediatric Dosage
- Dosage varies based on weight and age. Consult a healthcare provider.
Geriatric Dosage
- Lower doses may be required due to decreased renal function.
Side Effects
- Diarrhea
- Abdominal cramping
- Nausea
- Vomiting
Contraindications
- Hypersensitivity to magnesium oxide
- Renal failure
- Myasthenia gravis
Pregnancy Category
- C - Use with caution
Lactation Safety
- Compatible with breastfeeding in recommended doses
Drug Interactions
- Interacts with certain antibiotics, bisphosphonates, and diuretics. Consult healthcare provider.
Overdose Symptoms
- Severe diarrhea
- Abdominal pain
- Weakness
- Confusion
Antidote for Overdose
- Calcium gluconate or calcium chloride may be used.
Storage Conditions
- Store at room temperature away from moisture and heat.
Pharmacokinetics
- Absorption: Poorly absorbed in the gastrointestinal tract
- Distribution: Distributed in extracellular fluids
- Metabolism: Not significantly metabolized
- Excretion: Excreted renally
Precautions
- Monitor magnesium levels in patients with renal impairment
- Avoid in patients with bowel obstruction
Warnings
- Do not exceed recommended dosage
- Consult a healthcare provider before use in certain medical conditions or with other medications.
Others
- May interact with certain food and beverages, such as high-fiber foods or dairy products.