Niraparib

Generic Details

Generic Name

Niraparib

Other Names

    Drug Class

    • PARP inhibitor

    Chemical Formula

    C19H20N4O2

    Molecular Weight

    320.39 g/mol

    Mechanism of Action

    • Inhibits poly (ADP-ribose) polymerase (PARP) enzymes, which play a role in DNA repair processes, leading to cancer cell death.

    Indications

    • Ovarian cancer
    • Breast cancer
    • Fallopian tube cancer
    • Primary peritoneal cancer

    Common Dosage Forms

    • Capsules

    Typical Dosage

    • 300 mg once daily

    Pediatric Dosage

      Geriatric Dosage

        Side Effects

        • Nausea
        • Fatigue
        • Thrombocytopenia
        • Anemia
        • Constipation
        • Vomiting
        • Diarrhea
        • Musculoskeletal pain

        Contraindications

        • Hypersensitivity to niraparib

        Pregnancy Category

        • D

        Lactation Safety

        • May not be safe during breastfeeding

        Drug Interactions

        • Strong CYP3A4 inhibitors/inducers
        • P-gp inhibitors/inducers

        Overdose Symptoms

        • Increased risk of myelosuppression and gastrointestinal toxicity

        Antidote for Overdose

        • No specific antidote, manage symptoms and provide supportive care

        Storage Conditions

        • Store at room temperature (20-25°C)
        • Protect from light and moisture

        Pharmacokinetics

        • Absorption: Well absorbed orally
        • Distribution: Extensively distributed in the body
        • Metabolism: Primarily hepatic via carboxylesterase 2 and CYP3A4
        • Excretion: Mainly through feces

        Precautions

        • Monitor blood counts regularly during treatment
        • Use with caution in patients with renal impairment

        Warnings

        • Myelodysplastic syndrome/acute myeloid leukemia (MDS/AML) have been reported with niraparib

        Others

        • It is important to inform the healthcare provider about all medications, supplements, and herbal products being taken before starting niraparib.