Dienogest + Estradiol Valerate
Generic Details
Generic Name
Dienogest-Estradiol-Valerate
Other Names
- Dienogest/Estradiol/Valerate
- Natazia
- Qlaira
Drug Class
- Combination oral contraceptive
Chemical Formula
Molecular Weight
Mechanism of Action
- Inhibition of ovulation
- Changes in cervical mucus viscosity
- Endometrial effects
Indications
- Oral contraception
Common Dosage Forms
- Oral tablets
Typical Dosage
- Take one tablet daily for 28 days in the specified order on the blister pack.
Pediatric Dosage
Geriatric Dosage
Side Effects
- Nausea
- Headache
- Breast tenderness
- Irregular bleeding
- Mood changes
- Weight changes
- Blood clots (rare but serious)
Contraindications
- History of blood clots
- Smoking while using this medication
- Liver disease
- Uncontrolled high blood pressure
Pregnancy Category
- X - Contraindicated in pregnancy
Lactation Safety
- Should not be used while breastfeeding
Drug Interactions
- Rifampicin
- St. John's wort
- Certain anticonvulsants
Overdose Symptoms
- Nausea
- Vomiting
- Withdrawal bleeding
Antidote for Overdose
- Symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat.
Pharmacokinetics
- Absorption: Well absorbed after oral administration
- Distribution: Binds to serum albumin and sex hormone-binding globulin
- Metabolism: Undergoes hepatic metabolism
- Excretion: Excreted in feces and urine
Precautions
- Regular monitoring for blood pressure and cardiovascular risk factors
Warnings
- Increased risk of blood clots
- Cigarette smoking increases the risk of serious cardiovascular side effects
Others
- May cause changes in menstrual bleeding pattern during the first few months of use.