Menaquinone-7

Generic Details

Generic Name

Menaquinone-7

Other Names

  • Vitamin K2-7

Drug Class

  • Vitamin

Chemical Formula

C46H64O2

Molecular Weight

648.990 g/mol

Mechanism of Action

  • Acts as a cofactor for the gamma-carboxylation of specific glutamic acid residues in proteins involved in blood coagulation and bone metabolism.

Indications

  • Vitamin K2 deficiency
  • Supports bone health
  • Cardiovascular health

Common Dosage Forms

  • Tablet
  • Capsule
  • Liquid

Typical Dosage

  • 45-180 mcg per day for adults

Pediatric Dosage

  • Consult healthcare provider for appropriate dosage

Geriatric Dosage

  • Adjust dosage based on individual needs

Side Effects

  • Rare cases of allergic reactions
  • GI disturbances if taken in high doses

Contraindications

  • Hypersensitivity to vitamin K
  • Use with caution in patients on anticoagulant therapy

Pregnancy Category

  • Consult healthcare provider

Lactation Safety

  • Considered safe when consumed in dietary amounts

Drug Interactions

  • Warfarin and other anticoagulants

Overdose Symptoms

  • Excessive blood clotting

Antidote for Overdose

  • Phylloquinone (Vitamin K1)

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Well absorbed from the gastrointestinal tract
  • Distribution: Binds to lipoproteins and is transported in the bloodstream
  • Metabolism: Metabolized in the liver
  • Excretion: Excreted mainly in the feces

Precautions

  • Caution in patients with clotting disorders
  • Monitor INR in patients on anticoagulants

Warnings

  • Do not exceed recommended dosage
  • Keep out of reach of children

Others

  • Some formulations may contain soy or other allergens. Check ingredients for allergies.