Baloxavir Marboxil

Generic Name

Baloxavir-marboxil

Other Names

• Xofluza

Drug Class

• Antiviral

Chemical Formula

C27H23F4N4O7

Molecular Weight

571.5 g/mol

Mechanism of Action

• Inhibition of viral RNA polymerase

Indications

• Treatment of acute uncomplicated influenza in patients aged 12 years and older

Common Dosage Forms

• Tablet

Typical Dosage

• 40 mg as a single oral dose

Pediatric Dosage

• Not approved for children under 12 years

Geriatric Dosage

• No specific dosage adjustments mentioned

Side Effects

• Nausea
• Diarrhea
• Headache
• Fatigue

Contraindications

• Hypersensitivity to baloxavir-marboxil

Pregnancy Category

• Category C - Animal reproduction studies have shown an adverse effect on the fetus

Lactation Safety

• No data available, cautious use recommended

Drug Interactions

• Co-administration with polyvalent cation-containing products may reduce efficacy

Overdose Symptoms

• No specific overdose symptoms reported

Antidote for Overdose

• Symptomatic treatment and monitoring

Storage Conditions

• Store at room temperature away from moisture and heat

Pharmacokinetics

• Absorption: Rapidly absorbed after oral administration
• Distribution: High volume of distribution
• Metabolism: Primarily hepatic metabolism
• Excretion: Mainly excreted in feces

Precautions

• Monitor for signs of allergic reactions

Warnings

• Risk of emergence of drug-resistant influenza viruses with prolonged use

Others

• Baloxavir-marboxil is a novel antiviral medication with a unique mechanism of action.