Carbimazole
Generic Details
Generic Name
Carbimazole
Other Names
- Neomercazole
Drug Class
- Antithyroid agent
Chemical Formula
C7H10N2O2S
Molecular Weight
186.24 g/mol
Mechanism of Action
- Inhibits thyroid hormone synthesis by blocking the enzyme thyroperoxidase
Indications
- Hyperthyroidism
- Graves' disease
Common Dosage Forms
- Tablet
Typical Dosage
- 5-40 mg daily in divided doses
Pediatric Dosage
- Not established
Geriatric Dosage
- Dose reduction may be needed
Side Effects
- Nausea
- Vomiting
- Rash
- Agranulocytosis
- Hepatotoxicity
Contraindications
- Hypersensitivity to carbimazole
- Pregnancy
Pregnancy Category
- D
Lactation Safety
- Limited data available, caution advised
Drug Interactions
- Warfarin
- Theophylline
- Propranolol
Overdose Symptoms
- Severe hypothyroidism
- Loss of consciousness
Antidote for Overdose
- Supportive care
- Thyroid hormone replacement therapy
Storage Conditions
- Store in a cool, dry place away from light
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract
- Distribution: Crosses the placenta and enters breast milk
- Metabolism: Hepatic
- Excretion: Mainly renal
Precautions
- Regular monitoring of thyroid function tests
Warnings
- May cause agranulocytosis, liver failure, and severe skin reactions