Indapamide + Amlodipine

Generic Details

Generic Name

Indapamide-Amlodipine

Other Names

  • Indapamide-Amlodipine Combination

Drug Class

  • Antihypertensive combination

Chemical Formula

Molecular Weight

Mechanism of Action

  • Indapamide acts primarily by blocking sodium reabsorption in the distal convoluted tubules.
  • Amlodipine is a calcium channel blocker that inhibits the influx of calcium ions into smooth muscle cells of the heart and blood vessels.

Indications

  • Hypertension (high blood pressure)

Common Dosage Forms

  • Tablet

Typical Dosage

  • Indapamide 1.25 mg - Amlodipine 5 mg once daily

Pediatric Dosage

  • Safety and efficacy not established in children

Geriatric Dosage

  • Dosing adjustments may be needed based on renal function

Side Effects

  • Hypotension (low blood pressure)
  • Headache
  • Edema
  • Dizziness
  • Flushing

Contraindications

  • Known hypersensitivity to indapamide, amlodipine, or any other component of the formulation
  • Severe hepatic impairment
  • Severe renal impairment (CrCl <30 ml/min)

Pregnancy Category

  • Category C - Risk cannot be ruled out

Lactation Safety

  • Lactation is not recommended due to the potential risk to the infant

Drug Interactions

  • Concomitant use with other antihypertensives may potentiate hypotensive effects
  • Caution with cytochrome P450 3A4 inhibitors and inducers

Overdose Symptoms

  • Excessive hypotension
  • Bradycardia (slow heart rate)
  • Possible fluid and electrolyte disturbances

Antidote for Overdose

  • Symptomatic and supportive treatment

Storage Conditions

  • Store at room temperature (20-25°C)

Pharmacokinetics

  • Absorption: Indapamide - Well-absorbed orally, Amlodipine - Well-absorbed orally
  • Distribution: Protein binding: Indapamide - ~79%, Amlodipine - ~98%
  • Metabolism: Indapamide - Hepatic; Amlodipine - Hepatic
  • Excretion: Indapamide - Renal, Amlodipine - Fecal and renal

Precautions

  • Caution in patients with electrolyte disturbances
  • Monitor blood pressure regularly

Warnings

  • Avoid sudden discontinuation as rebound hypertension may occur
  • Risk of hypotension particularly in volume-depleted or patients with severe aortic stenosis

Others