Atorvastatin + Ezetimibe

Generic Details

Generic Name

Atorvastatin-Ezetimibe

Other Names

  • Ator-Ez
  • Atorvastatin and Ezetimibe Combination

Drug Class

  • Cholesterol Absorption Inhibitors
  • HMG-CoA Reductase Inhibitors

Chemical Formula

Molecular Weight

Mechanism of Action

  • Atorvastatin: HMG-CoA Reductase Inhibitor reducing cholesterol synthesis
  • Ezetimibe: Blocks absorption of cholesterol in the small intestine

Indications

  • Hypercholesterolemia
  • Mixed dyslipidemia

Common Dosage Forms

  • Tablet

Typical Dosage

  • Atorvastatin 10-80 mg with ezetimibe 10 mg once daily

Pediatric Dosage

    Geriatric Dosage

      Side Effects

      • Muscle pain (myalgia)
      • Liver enzyme abnormalities
      • Diarrhea
      • Nausea
      • Headache

      Contraindications

      • Hypersensitivity to atorvastatin or ezetimibe
      • Active liver disease

      Pregnancy Category

      • Category X - Not recommended during pregnancy

      Lactation Safety

      • Lactation not recommended as it is unknown if the drug is excreted in human milk

      Drug Interactions

      • Simvastatin
      • Cyclosporine
      • Warfarin

      Overdose Symptoms

      • Muscle pain and weakness
      • Rhabdomyolysis

      Antidote for Overdose

      • Symptomatic treatment and monitoring

      Storage Conditions

      • Store at room temperature away from moisture and heat

      Pharmacokinetics

      • Absorption: Well absorbed from the gastrointestinal tract
      • Distribution: Atorvastatin: Enters breast milk, Ezetimibe: Unknown if distributed in human milk
      • Metabolism: Extensively metabolized in the liver
      • Excretion: Atorvastatin: Excreted in bile and urine, Ezetimibe: Excreted in feces (78%) and urine (11%)

      Precautions

      • Monitor liver function tests periodically
      • Report any unexplained muscle pain or weakness

      Warnings

      • Risk of myopathy and rhabdomyolysis with atorvastatin
      • Liver enzyme abnormalities