Roxadustat
Generic Details
Generic Name
Roxadustat
Other Names
- Roxadustat
- FG-4592
Drug Class
- Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor
Chemical Formula
C19H16N2O5
Molecular Weight
360.34 g/mol
Mechanism of Action
- Stimulates the body to produce more red blood cells by mimicking the response to hypoxia
Indications
- Treatment of anemia in patients with chronic kidney disease (CKD)
Common Dosage Forms
- Tablet
Typical Dosage
- 100-300 mg once per day, orally
Pediatric Dosage
- Not established
Geriatric Dosage
- Dose adjustment may be required based on renal function
Side Effects
- Nausea
- Diarrhea
- Hypertension
- Peripheral edema
- Hyperkalemia
Contraindications
- Hypersensitivity to roxadustat
- Uncontrolled hypertension
Pregnancy Category
- Not recommended
Lactation Safety
- Not recommended, decide to discontinue breastfeeding or the drug depending on the importance of the medicine to the mother
Drug Interactions
- May interact with drugs that affect the renin-angiotensin-aldosterone system
Overdose Symptoms
- Risk of hypotension, tachycardia, and dehydration
Antidote for Overdose
- Supportive measures, such as fluid intake and blood pressure monitoring
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed after oral administration
- Distribution: Protein-bound
- Metabolism: Primarily metabolized by the liver
- Excretion: Excreted in the urine
Precautions
- Monitor blood pressure regularly during treatment
Warnings
- May increase the risk of cardiovascular events and thromboembolism
Others
- Regular monitoring of hemoglobin levels and iron status is recommended during treatment.