Alpha Lipoic Acid
Generic Details
Generic Name
Alpha-Lipoic Acid
Other Names
- Thioctic Acid
- ALA
Drug Class
- Antioxidant
Chemical Formula
C8H14O2S2
Molecular Weight
206.33 g/mol
Mechanism of Action
- Acts as a cofactor for mitochondrial enzymes involved in energy metabolism
- Regenerates antioxidants such as Vitamin C and Vitamin E
Indications
- Diabetic neuropathy
- Peripheral neuropathy
- Antioxidant support
Common Dosage Forms
- Oral tablets
- Capsules
Typical Dosage
- 600-1800mg per day in divided doses
Pediatric Dosage
- Not established
Geriatric Dosage
- Dosing adjustment may be needed based on renal function
Side Effects
- Nausea
- Vomiting
- Rash
- Hypoglycemia in diabetic patients
Contraindications
- Hypersensitivity to Alpha-Lipoic Acid
Pregnancy Category
- C
Lactation Safety
- Not established, use with caution
Drug Interactions
- Insulin and other antidiabetic medications
- Thyroid medications
Overdose Symptoms
- Hypoglycemia
- Nausea
- Vomiting
Antidote for Overdose
- Supportive care and monitoring
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed after oral administration
- Distribution: Widely distributed in the body
- Metabolism: Primarily metabolized in the liver
- Excretion: Mainly excreted in the urine
Precautions
- Monitor blood glucose levels in diabetic patients
- Use with caution in patients with thyroid disorders
Warnings
- Consult healthcare provider before use if pregnant or breastfeeding
Others
- May improve insulin sensitivity in diabetic patients