Finerenone
Generic Details
Generic Name
Finerenone
Other Names
- BAY 94-8862
Drug Class
- Mineralocorticoid receptor antagonist
Chemical Formula
C29H28Cl2O3
Molecular Weight
521.44 g/mol
Mechanism of Action
- Selective blockade of the mineralocorticoid receptor
Indications
- Treatment of chronic kidney disease in patients with type 2 diabetes and albuminuria
Common Dosage Forms
- Tablet
Typical Dosage
- 5-20 mg once daily
Pediatric Dosage
- The safety and efficacy in pediatric patients have not been established
Geriatric Dosage
- No dosage adjustment is necessary based on age
Side Effects
- Hypokalemia
- Hyperkalemia
- Dizziness
- Fatigue
- Gastrointestinal disturbances
Contraindications
- Hypersensitivity to finerenone
- Severe renal impairment (eGFR <30 mL/min/1.73 m2)
Pregnancy Category
- Not recommended during pregnancy
Lactation Safety
- It is unknown whether finerenone is excreted in human milk
Drug Interactions
- Potassium-sparing diuretics
- ACE inhibitors
- ARBs
Overdose Symptoms
- Bradycardia
- Hypotension
- Hyperkalemia
Antidote for Overdose
- Discontinue finerenone, monitor electrolytes, and provide supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed after oral administration
- Distribution: Extensively bound to plasma proteins
- Metabolism: Metabolized by CYP3A enzymes
- Excretion: Mainly excreted in feces
Precautions
- Monitor potassium levels regularly
- Caution in patients with hepatic impairment
Warnings
- Risk of hyperkalemia, especially in patients with impaired renal function