Cefaclor Monohydrate
Generic Details
Generic Name
Cefaclor Monohydrate
Other Names
- Cefaclor
Drug Class
- Cephalosporin Antibiotic
Chemical Formula
C15H14ClN3O4S.H2O
Molecular Weight
385.82 g/mol
Mechanism of Action
- Inhibits bacterial cell wall synthesis
Indications
- Treatment of bacterial infections such as respiratory tract infections, urinary tract infections, skin and soft tissue infections, and otitis media
Common Dosage Forms
- Capsules
- Oral suspension
Typical Dosage
- 250-500 mg every 8 hours for adults
Pediatric Dosage
- 20 mg/kg/day in divided doses
Geriatric Dosage
- Adjust dose based on renal function
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Rash
- Allergic reactions
Contraindications
- Hypersensitivity to cephalosporins
Pregnancy Category
- Category B - Safe for use during pregnancy
Lactation Safety
- Compatible with breastfeeding
Drug Interactions
- Probenecid - may increase cefaclor levels
Overdose Symptoms
- Seizures
- Encephalopathy
Antidote for Overdose
- No specific antidote, treatment is symptomatic
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well-absorbed orally
- Distribution: Distributes well into tissues and fluids
- Metabolism: Partially metabolized in the liver
- Excretion: Excreted mainly through the kidneys
Precautions
- Use with caution in patients with renal impairment
Warnings
- May cause Clostridium difficile-associated diarrhea
Others
- Complete the full course of treatment as prescribed