Acemetacin
Generic Details
Generic Name
Acemetacin
Other Names
- Emflex
- Rantudil
Drug Class
- Nonsteroidal Anti-Inflammatory Drug (NSAID)
Chemical Formula
C16H13ClN2O4
Molecular Weight
309.74 g/mol
Mechanism of Action
- Inhibition of prostaglandin synthesis via COX-1 and COX-2 enzymes
Indications
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Pain management
Common Dosage Forms
- Tablet
- Capsule
Typical Dosage
- Normally 90-120 mg daily in divided doses
Pediatric Dosage
- Not recommended for children
Geriatric Dosage
- May require dosage adjustment based on renal function
Side Effects
- Gastrointestinal disturbances
- Ulcers
- Bleeding
- Renal impairment
- Headache
- Dizziness
Contraindications
- Peptic ulcer disease
- Severe heart failure
- Severe renal impairment
- Third trimester of pregnancy
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Not recommended, excreted in breast milk
Drug Interactions
- Anticoagulants
- Lithium
- Diuretics
- ACE inhibitors
Overdose Symptoms
- Nausea
- Vomiting
- Abdominal pain
- Hypotension
Antidote for Overdose
- No specific antidote, symptomatic and supportive treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Protein-bound, penetrates synovial fluid
- Metabolism: Hepatic metabolism to active metabolites
- Excretion: Primarily renal excretion
Precautions
- Monitor for signs of gastrointestinal bleeding
- Avoid in patients with renal impairment
- Caution in elderly patients
Warnings
- Increased risk of cardiovascular events
- May cause serious gastrointestinal adverse events