Cefadroxil Monohydrate
Generic Details
Generic Name
Cefadroxil Monohydrate
Other Names
- Duricef
Drug Class
- First-generation cephalosporin
Chemical Formula
C16H17N3O5S.H2O
Molecular Weight
381.39 g/mol
Mechanism of Action
- Inhibits bacterial cell wall synthesis
Indications
- Skin and soft tissue infections
- Urinary tract infections
- Respiratory tract infections
- Pharyngitis
Common Dosage Forms
- Capsules
- Oral suspension
Typical Dosage
- Adults: 1-2 grams per day divided every 12 hours
- Children: 30 mg/kg/day divided every 12 hours
Pediatric Dosage
- 30 mg/kg/day divided every 12 hours
Geriatric Dosage
- Dosage adjustment may be required based on renal function
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Rash
- Hypersensitivity reactions
Contraindications
- Hypersensitivity to cephalosporins
Pregnancy Category
- Category B - No proven risk in humans
Lactation Safety
- Safe to use while breastfeeding
Drug Interactions
- Probenecid - may increase serum levels of cefadroxil
Overdose Symptoms
- Seizures
- Encephalopathy
Antidote for Overdose
- No specific antidote, symptomatic treatment
Storage Conditions
- Store at room temperature (15-30°C)
- Protect from moisture
Pharmacokinetics
- Absorption: Well-absorbed from the GI tract
- Distribution: Distributed widely in body tissues
- Metabolism: Minimal metabolism
- Excretion: Primarily excreted unchanged in urine
Precautions
- Caution in patients with renal impairment
Warnings
- May cause Clostridium difficile-associated diarrhea
Others
- Complete the full course of treatment as prescribed.