Cefditoren

Generic Name

Cefditoren

Other Names

• Spectracef

Drug Class

• Third-generation cephalosporin antibiotic

Chemical Formula

C19H18N5O5S2

Molecular Weight

478.51 g/mol

Mechanism of Action

• Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins

Indications

• Cefditoren is used for the treatment of respiratory tract infections, skin and soft tissue infections, urinary tract infections, and community-acquired pneumonia.

Common Dosage Forms

• Oral tablets
• Oral suspension

Typical Dosage

• 200-400 mg every 12 hours

Pediatric Dosage

• Safety and efficacy not established in children under 12 years old

Geriatric Dosage

• Dose adjustment may be needed in elderly patients

Side Effects

• Common side effects include diarrhea, nausea, vomiting, headache, and rash.

Contraindications

• Hypersensitivity to cephalosporins or penicillins

Pregnancy Category

• Category B - Animal reproduction studies have failed to demonstrate a risk to the fetus, but there are no adequate and well-controlled studies in pregnant women.

Lactation Safety

• Compatible with breastfeeding, monitor infant for potential gastrointestinal disturbances.

Drug Interactions

• May interact with probenecid and certain nephrotoxic drugs.

Overdose Symptoms

• May include neurological symptoms such as encephalopathy or seizures.

Antidote for Overdose

• No specific antidote, manage symptoms and provide supportive care.

Storage Conditions

• Store at room temperature away from moisture and heat.

Pharmacokinetics

• Absorption: Well absorbed after oral administration
• Distribution: Distributes well into various body tissues and fluids
• Metabolism: Partially metabolized in the liver
• Excretion: Excreted primarily unchanged in the urine

Precautions

• Use with caution in patients with renal impairment

Warnings

• May cause Clostridium difficile-associated diarrhea

Others

• Always complete the full course of treatment as prescribed by the healthcare provider.