Cholestyramine Resin
Generic Details
Generic Name
Cholestyramine-Resin
Other Names
- Questran
- Prevalite
- Cholybar
Drug Class
- Bile Acid Sequestrant
Chemical Formula
Not applicable (polymeric resin)
Molecular Weight
Not applicable
Mechanism of Action
- Cholestyramine resin binds bile acids in the intestine, forming insoluble complexes that are excreted in the feces. This leads to a reduction in plasma cholesterol concentration.
Indications
- Primary hypercholesterolemia
- Pruritus associated with elevated bile acids
Common Dosage Forms
- Powder for Suspension
- Tablet
Typical Dosage
- 4 grams once or twice daily
Pediatric Dosage
- Dosage based on weight, to be determined by a healthcare provider
Geriatric Dosage
- Dosage adjustments may be necessary in elderly patients
Side Effects
- Constipation
- Abdominal discomfort
- Flatulence
- Nausea
- Vomiting
Contraindications
- Complete biliary obstruction
- Known hypersensitivity to cholestyramine
Pregnancy Category
- C - Risk cannot be ruled out
Lactation Safety
- Limited data available, caution advised
Drug Interactions
- Interferes with absorption of many drugs, administer other medications 1 hour before or 4-6 hours after cholestyramine
Overdose Symptoms
- Severe constipation
- Obstruction of the bowel
Antidote for Overdose
- Not applicable, provide supportive care for overdose symptoms
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Not absorbed systemically
- Distribution: Not applicable
- Metabolism: Not metabolized
- Excretion: Excreted unchanged in the feces
Precautions
- Monitor for vitamin deficiencies
- Consider use of vitamin supplements
Warnings
- May interfere with absorption of fat-soluble vitamins
- Increase fluid intake to prevent constipation