Cefepime Hydrochloride
Generic Details
Generic Name
Cefepime Hydrochloride
Other Names
- Maxipime
Drug Class
- Fourth Generation Cephalosporin
Chemical Formula
C19H24N6O5S2.HCl
Molecular Weight
480.01 g/mol
Mechanism of Action
- Cefepime exerts its bactericidal activity by inhibiting bacterial cell wall synthesis.
Indications
- Treatment of moderate to severe infections caused by susceptible bacteria.
Common Dosage Forms
- Injection
- Powder for solution
Typical Dosage
- 1-2 grams every 12 hours, dose and duration varies with the type and severity of infection.
Pediatric Dosage
- Dosing based on weight and age, administered every 8-12 hours.
Geriatric Dosage
- Adjusted dosing considering renal function and other comorbidities.
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Rash
- Injection site reactions
Contraindications
- Known allergy to cephalosporins or beta-lactams
Pregnancy Category
- Category B - No evidence of risk in humans
Lactation Safety
- Considered compatible with breastfeeding
Drug Interactions
- May interact with aminoglycosides, diuretics, and probenecid.
Overdose Symptoms
- Seizures
- Encephalopathy
Antidote for Overdose
- No specific antidote, manage symptoms and provide supportive care.
Storage Conditions
- Store at room temperature, protected from light and moisture.
Pharmacokinetics
- Absorption: Well absorbed after intramuscular or intravenous administration.
- Distribution: Distributes well into various tissues and fluids.
- Metabolism: Minimal metabolism in the body.
- Excretion: Primarily excreted unchanged in the urine.
Precautions
- Use with caution in patients with renal impairment.
Warnings
- Risk of Clostridium difficile-associated diarrhea.
Others
- Cefepime is often reserved for serious infections due to its broad spectrum and potential for developing resistance.