Cefixime Trihydrate
Generic Details
Generic Name
Cefixime Trihydrate
Other Names
- Suprax
Drug Class
- Third-generation cephalosporin antibiotic
Chemical Formula
C16H15N5O7S2
Molecular Weight
453.45 g/mol
Mechanism of Action
- Inhibits bacterial cell wall synthesis
Indications
- Treatment of respiratory tract infections
- Urinary tract infections
- Ear infections
- Gonorrhea
- Typhoid fever
Common Dosage Forms
- Tablet
- Oral suspension
Typical Dosage
- 400 mg once daily for most infections
Pediatric Dosage
- Doses vary based on the child's weight and age
Geriatric Dosage
- Lower doses may be recommended for the elderly
Side Effects
- Diarrhea
- Nausea
- Abdominal pain
- Headache
- Allergic reactions
Contraindications
- Hypersensitivity to cephalosporins
Pregnancy Category
- Category B - considered safe for use during pregnancy
Lactation Safety
- Considered safe while breastfeeding
Drug Interactions
- Probenecid may increase levels of cefixime
Overdose Symptoms
- Nausea
- Vomiting
- Diarrhea
Antidote for Overdose
- No specific antidote, symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed after oral administration
- Distribution: Distributes well into various tissues
- Metabolism: Partially metabolized in the liver
- Excretion: Excreted mainly via the urine
Precautions
- Use with caution in patients with renal impairment
Warnings
- May cause Clostridium difficile-associated diarrhea
Others
- Complete the full course of treatment as prescribed by the healthcare provider.