Exemestane
Generic Details
Generic Name
Exemestane
Other Names
- Aromasin
Drug Class
- Aromatase Inhibitor
Chemical Formula
C20H24O2
Molecular Weight
296.403 g/mol
Mechanism of Action
- Blocks the aromatase enzyme, reducing estrogen production
Indications
- Treatment of breast cancer in postmenopausal women
Common Dosage Forms
- Tablet
Typical Dosage
- 25 mg once daily after a meal
Pediatric Dosage
- Not established
Geriatric Dosage
- Adjust dose based on individual patient needs
Side Effects
- Hot flashes
- Fatigue
- Joint pain
- Headache
- Increased sweating
Contraindications
- Pregnancy
- Pre-menopausal women
- Severe liver impairment
Pregnancy Category
- X - Contraindicated
Lactation Safety
- Not recommended during breastfeeding
Drug Interactions
- Estrogen-containing therapies
- CYP3A4 inducers/inhibitors
Overdose Symptoms
- Nausea
- Vomiting
- Dizziness
Antidote for Overdose
- No specific antidote, symptomatic treatment
Storage Conditions
- Store at room temperature, away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Highly protein-bound
- Metabolism: Metabolized in the liver
- Excretion: Primarily in feces
Precautions
- Monitor bone health
- Monitor lipid levels
- Regular liver function tests
Warnings
- Increased risk of osteoporosis
- Increased risk of cardiovascular events
Others
- Avoid grapefruit and grapefruit juice due to CYP3A4 interactions