Cefpodoxime Proxetil

Generic Name

Cefpodoxime-proxetil

Other Names

• Vantin

Drug Class

• Third-generation cephalosporin antibiotic

Chemical Formula

C21H27N5O9S2

Molecular Weight

557.6 g/mol

Mechanism of Action

• Inhibits bacterial cell wall synthesis

Indications

• Upper respiratory tract infections
• Skin and soft tissue infections
• Urinary tract infections

Common Dosage Forms

• Tablet
• Oral suspension

Typical Dosage

• 200-400 mg twice daily for most infections

Pediatric Dosage

• Dosing based on weight and severity of infection

Geriatric Dosage

• Adjust dosing based on renal function

Side Effects

• Diarrhea
• Nausea
• Vomiting
• Headache
• Rash

Contraindications

• Known allergy to cephalosporin antibiotics

Pregnancy Category

• Category B - No evidence of risk in humans

Lactation Safety

• Considered compatible with breastfeeding

Drug Interactions

• Probenecid - may increase cefpodoxime levels

Overdose Symptoms

• Seizures
• Encephalopathy

Antidote for Overdose

• No specific antidote, symptomatic treatment

Storage Conditions

• Store at room temperature away from moisture and heat

Pharmacokinetics

• Absorption: Well-absorbed orally
• Distribution: Distributed widely into body tissues and fluids
• Metabolism: Partially metabolized in the liver
• Excretion: Primarily excreted unchanged in the urine

Precautions

• Use with caution in patients with renal impairment

Warnings

• May cause Clostridium difficile-associated diarrhea
• Prolonged use may result in superinfection

Others

• Take with food to enhance absorption