Ceftibuten Dihydrate
Generic Details
Generic Name
Ceftibuten Dihydrate
Other Names
- Cedax
Drug Class
- Third-generation cephalosporin
Chemical Formula
C15H14N4O6S2.2H2O
Molecular Weight
474.48 g/mol
Mechanism of Action
- Inhibits bacterial cell wall synthesis
Indications
- Acute bacterial exacerbation of chronic bronchitis
- Acute bacterial otitis media
- Pharyngitis/Tonsillitis
- Uncomplicated urinary tract infections
Common Dosage Forms
- Capsules
- Oral suspension
Typical Dosage
- 400 mg once daily for 10 days for most infections
Pediatric Dosage
- For children, the dosage is weight-based and varies
Geriatric Dosage
- Dosage adjustment may be needed in elderly patients with renal impairment
Side Effects
- Diarrhea
- Nausea
- Headache
- Vaginitis
- Rash
Contraindications
- Hypersensitivity to cephalosporins
Pregnancy Category
- Category B - No evidence of risk in humans
Lactation Safety
- Generally considered safe during breastfeeding
Drug Interactions
- Probenecid can increase ceftibuten levels
Overdose Symptoms
- Nausea
- Vomiting
- Diarrhea
Antidote for Overdose
- Supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed after oral administration
- Distribution: Widely distributed in body tissues
- Metabolism: Partially metabolized in the liver
- Excretion: Primarily excreted unchanged in the urine
Precautions
- Use with caution in patients with renal impairment
Warnings
- May cause Clostridium difficile-associated diarrhea
Others
- Always complete the full course of treatment even if symptoms improve earlier.