Cefuroxime Axetil
Generic Details
Generic Name
Cefuroxime Axetil
Other Names
- Ceftin
- Zinacef
Drug Class
- Second-generation cephalosporin
Chemical Formula
C20H22N4O10S
Molecular Weight
510.47 g/mol
Mechanism of Action
- Cefuroxime axetil is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis.
Indications
- Upper respiratory tract infections
- Lower respiratory tract infections
- Skin and soft tissue infections
- Urinary tract infections
Common Dosage Forms
- Tablet
- Suspension
Typical Dosage
- 250-500 mg twice daily for 7-10 days
Pediatric Dosage
- Dosing based on weight and age; consult pediatrician
Geriatric Dosage
- Dosing adjustments may be necessary; consult healthcare provider
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Allergic reactions
- Headache
Contraindications
- Known allergy to cephalosporins
Pregnancy Category
- Category B - Safe for use during pregnancy based on limited data
Lactation Safety
- Safe to use while breastfeeding; monitor for diarrhea or rash in the infant
Drug Interactions
- Probenecid can increase blood levels of cefuroxime axetil
Overdose Symptoms
- Seizures
- Encephalopathy
Antidote for Overdose
- No specific antidote; symptomatic and supportive treatment
Storage Conditions
- Store at room temperature below 30°C (86°F); protect from moisture and light
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Distributes widely into tissues and body fluids
- Metabolism: Partially metabolized in the liver
- Excretion: Primarily excreted unchanged in the urine
Precautions
- Use with caution in patients with renal impairment
- Avoid in patients with a history of gastrointestinal disease
Warnings
- May cause Clostridium difficile-associated diarrhea (CDAD)
- Risk of anaphylaxis in patients with penicillin allergy