Cephalexin
Generic Details
Generic Name
Cephalexin
Other Names
- Keflex
- Ceporex
Drug Class
- First-generation cephalosporin antibiotic
Chemical Formula
C16H17N3O4S
Molecular Weight
349.39 g/mol
Mechanism of Action
- Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins
Indications
- Treatment of skin and soft tissue infections
- Respiratory tract infections
- Urinary tract infections
- Bone infections
Common Dosage Forms
- Capsule
- Tablet
- Oral suspension
Typical Dosage
- 250-500 mg every 6 hours
Pediatric Dosage
- 25-50 mg/kg/day in divided doses
Geriatric Dosage
- Dose adjustment may be required based on renal function
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Rash
- Hypersensitivity reactions
Contraindications
- Hypersensitivity to cephalosporins
- History of severe allergic reactions to penicillins
Pregnancy Category
- Category B - Generally considered safe for use during pregnancy
Lactation Safety
- Considered compatible with breastfeeding
Drug Interactions
- Probenecid - may increase cephalexin levels
Overdose Symptoms
- Nausea
- Vomiting
- Diarrhea
Antidote for Overdose
- No specific antidote, supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Distributed widely in the body
- Metabolism: Minimally metabolized
- Excretion: Excreted unchanged in urine
Precautions
- Use with caution in patients with renal impairment
Warnings
- Potential for allergic reactions in patients with penicillin allergies