Dexamethasone + Chloramphenicol
Generic Details
Generic Name
Dexamethasone-Chloramphenicol
Other Names
Drug Class
- Corticosteroid
- Antibiotic
Chemical Formula
Molecular Weight
Mechanism of Action
- Dexamethasone: Anti-inflammatory and immunosuppressant properties by inhibiting the release of inflammatory mediators. Chloramphenicol: Inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit.
Indications
- External otitis
- Ocular infections
- Ophthalmic inflammation
Common Dosage Forms
- Ointment
- Eye drops
Typical Dosage
Pediatric Dosage
Geriatric Dosage
Side Effects
- Local irritation
- Redness
- Burning sensation
- Allergic reactions
- Secondary infections
Contraindications
- Hypersensitivity to dexamethasone or chloramphenicol
- Viral or fungal infections of the eye or ear
Pregnancy Category
- C for dexamethasone
- C for chloramphenicol
Lactation Safety
- Use with caution, monitor the infant for any adverse effects
Drug Interactions
- None reported
Overdose Symptoms
Antidote for Overdose
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption:
- Distribution:
- Metabolism:
- Excretion:
Precautions
- Monitor for secondary infections
- Avoid contact with eyes when using ointment
Warnings
- Long-term use may lead to glaucoma or cataracts