Chlorpheniramine Maleate
Generic Details
Generic Name
Chlorpheniramine-Maleate
Other Names
- Chlorpheniramine Maleate
Drug Class
- Antihistamine
Chemical Formula
C20H23ClN2O4
Molecular Weight
390.86 g/mol
Mechanism of Action
- Competitive histamine H1 receptor antagonist
Indications
- Allergic rhinitis
- Allergic conjunctivitis
- Allergic dermatitis
- Pruritus
- Urticaria
Common Dosage Forms
- Tablet
- Syrup
- Injection
Typical Dosage
- 4mg to 8mg every 4 to 6 hours as needed
Pediatric Dosage
- Dosage varies based on age and weight, consult a pediatrician
Geriatric Dosage
- Lower initial doses may be necessary due to decreased liver and kidney function
Side Effects
- Drowsiness
- Dry mouth
- Blurred vision
- Urinary retention
Contraindications
- Narrow-angle glaucoma
- Urinary retention
- Severe liver disease
Pregnancy Category
- Category B - No evidence of risk in humans
Lactation Safety
- Should be used with caution as it is excreted in breast milk
Drug Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Central Nervous System depressants
Overdose Symptoms
- Severe drowsiness
- Convulsions
- Coma
Antidote for Overdose
- No specific antidote, supportive care
Storage Conditions
- Store in a cool, dry place away from sunlight
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract
- Distribution: Crosses the blood-brain barrier and placenta; excreted in breast milk
- Metabolism: Metabolized in the liver
- Excretion: Excreted mainly in the urine
Precautions
- Use with caution in patients with prostatic hypertrophy
- May cause drowsiness, avoid driving or operating machinery
Warnings
- Avoid alcohol consumption while taking this medication
Others
- Do not use in children under 2 years of age unless directed by a healthcare provider