Acitretin
Generic Details
Generic Name
Acitretin
Other Names
- Soriatane
Drug Class
- Retinoid
Chemical Formula
C21H26O3
Molecular Weight
326.43 g/mol
Mechanism of Action
- Acitretin is a synthetic retinoid that modulates epithelial cell growth and differentiation.
Indications
- Severe psoriasis
- Darier's disease
- Palmoplantar pustulosis
Common Dosage Forms
- Capsule
Typical Dosage
- 25-50 mg once daily with food
Pediatric Dosage
- Safety and efficacy not established
Geriatric Dosage
- Adjust dosage based on renal function
Side Effects
- Dry skin
- Pruritus
- Hair loss
- Elevated liver enzymes
- Photosensitivity
Contraindications
- Pregnancy
- Hypersensitivity to retinoids
- Severe hepatic or renal impairment
Pregnancy Category
- X
Lactation Safety
- Not recommended
Drug Interactions
- Methotrexate
- Tetracyclines
- Vitamin A supplements
Overdose Symptoms
- Headache
- Nausea
- Vomiting
- Dizziness
Antidote for Overdose
- There is no specific antidote, treatment is supportive
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Metabolites widely distributed in tissues
- Metabolism: Hepatic (CYP2C9 and CYP3A4)
- Excretion: Primarily in feces
Precautions
- Regular monitoring of liver function tests
- Avoid excess sun exposure
Warnings
- Potential for severe birth defects
- Potential for hepatotoxicity
Others
- Acitretin has a long half-life, and its effect may persist for several months after discontinuation.