Chlorthalidone
Generic Details
Generic Name
Chlorthalidone
Other Names
- Hygroton
- Thalitone
Drug Class
- Thiazide Diuretic
Chemical Formula
C14H11ClN2O4S
Molecular Weight
338.76 g/mol
Mechanism of Action
- Inhibits sodium reabsorption in the distal convoluted tubule of the kidney, leading to diuresis and decreased blood pressure
Indications
- Hypertension
- Edema
Common Dosage Forms
- Tablet
Typical Dosage
- 25-100 mg once daily
Pediatric Dosage
- Usage not recommended in children
Geriatric Dosage
- Lower initial doses may be considered in the elderly
Side Effects
- Hypokalemia
- Hyponatremia
- Hypomagnesemia
- Hypotension
- Dizziness
Contraindications
- Anuria
- Hypersensitivity to sulfonamides
Pregnancy Category
- Category B
Lactation Safety
- Compatible with breastfeeding
Drug Interactions
- NSAIDs may reduce the diuretic, natriuretic, and antihypertensive effects
Overdose Symptoms
- Electrolyte disturbances
- Hypovolemia
- Hypotension
Antidote for Overdose
- No specific antidote, treatment is supportive
Storage Conditions
- Store at room temperature away from light and moisture
Pharmacokinetics
- Absorption: Well-absorbed from the gastrointestinal tract
- Distribution: Widely distributed in the body
- Metabolism: Partially metabolized by the liver
- Excretion: Primarily excreted unchanged by the kidneys
Precautions
- Monitor electrolytes and renal function periodically
Warnings
- May cause severe dehydration and electrolyte imbalances if not used appropriately
Others
- Consider dose adjustments in patients with hepatic impairment